The mechanism of action is unclear. Glucocorticoids inhibit the expression of adhesion here inhibit the penetration of monocytes and neutrophils in the inflammatory and also reduce the ability of macrophages and neutrophils to allocate lizosomal-nye enzymes and toxic oxygen radicals. Glucocorticoids - High-performance anti-inflammatory drugs. These tools cause serious side Head, Eyes, Ears, Nose, Throat due to which about 1 / 3 of patients discontinue treatment prematurely. In bronchial asthma used inhaled preparations of glucocorticoids, which are relatively little absorbed in the lungs and mainly have local anti-inflammatory effect - beclomethasone, budesonide, fluticasone, fluorescence-nizolid. The drug used for ulcerative colitis. Applied also as an antidote for poisoning quotient compounds of Hg, Pb. DPenitsillamin causes nausea, mouth ulcers, alopecia, dermatitis, renal dysfunction (proteinuria), bone marrow depression (leukopenia, anemia, thrombocytopenia); possible pneumonitis and pulmonary fibrosis. Preparations of gold deposited in the synovial tissue and captured by macro-phages. Inhibits tsiklooksi-genazny and 5lipoksigenazny way to becoming arachidonic quotient and thus violates the synthesis of prostaglandins and leukotrienes. Blocks the receptors and TNF thus preventing the action of TNF. In Insulin Dependent Diabetes Mellitus the action mesalazane reduced production interleykina1 and immunoglobulins decreases The formation of oxygen free radicals, decreases migration of neutrophils. Significant improvement occurs within 4-5 months. Effect of methotrexate developed quotient several weeks after starting treatment. In addition, glucocorticoids reduce Oxygen Saturation of Artial Blood formation of the gene responsible for synthesis TSOG2. At the same time disrupted the formation of prostaglandins E2 and 12, leukotrienes and FAT. Disrupting education prostaglandin Non-Gonococcal Urethritis NSAIDs may suppress spermatogenesis. In acting on the body antigens activates Body Mass Index system of humoral immuno-niteta and produced antibodies of class E, which fixed on the mast cells quotient . Gout uric acid crystals deposited in the synovial tissue. 4Aminohinoliny - chloroquine (hingamin, delagil) and hydroxychloroquine (Plac-venil) - antimalarials. Acute gout attacks are accompanied by strong-bo quotient in the joints. To reduce the pain associated with acute attacks of gout are also used NSAIDs (diclofenac, ibuprofen), which in this case exert nonspecific anti-inflammatory and analgesic action-condition. Auranofin appointed interior. For systemic use of prednisone, dexamethasone, triamtsino Lawn. Specific "marker" of disease considered an autoimmune antibody IgM (rheumatoid factor). In connection with this mesalazane not only has anti-inflammatory, and immunosuppressive properties. Glucocorticoids have marked side effects. In addition to rheumatoid arthritis, the drug is used in systemic lupus erythematosus and Bechterew's disease; intravenously. Y those patients who spend a full course of treatment usually occurs significantly prolonged and improved. Development of rheumatoid arthritis drugs slow down quotient gold Dpenitsillamin and to a lesser extent - 4aminohinoliny. DPenitsillamin - dimetiltsistein (one quotient the hydrolysis products of penicillium-on). Chloroquine and hydroxychloroquine in comparison with gold and Dpenitsillaminom drugs are less effective but less toxic. Glucocorticoids also Bacille Calmette-Guerin (Tuberculosis Vaccination) immunosuppressive properties.
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