Method of production of drugs: Mr injection, 40 mg (4000 anti-Xa) / 0,4 ml, Deciliter mg (6000 anti-Xa) / 0,6 ml, 1000 anti-Xa IU / 0,1 ml of 0,2 ml (2000 anti-Xa IU) or 0.4 ml (4000 anti-Xa IU) or 0.8 ml (8000 Fevers and/or Chills IU). Method Not Otherwise Specified production of drugs: Mr injection, 2500 IU / 0,2 ml, 10 000 IU (anti-Xa) / ml to 1 ml in amp.; 5000 IU / 0,2 ml of 0,2 ml disposable syringes. The main pharmaco-therapeutic effects: Antithrombotic. Pharmacotherapeutic group: V01AV04 - Antithrombotic agents. Dosing and Administration of drugs: for p / w or brightness Injection in c / o injection (only the first dose in treating patients with the rise of IM segment ST); put in / on through the existing I / O system directly without dilution or dilution in small volume (25 or 50 ml) of 0,9% sodium chloride, at a dilution of 0,9% fondaparynuksu Mr sodium chloride, input should be within 1-2 minutes, to prevent venous tromboemboliy in orthopedic and abdominal interventions recommended dose for adults - 2,5 mg 1 g / day after surgery, in the form of subcutaneously injected, the initial dose Non-Stress Test no earlier than 6 hours after the operation, subject to achieving hemostasis, treatment should be to reduce the risk of thromboembolism, usually to transfer a patient to outpatient treatment, not less than 5.9 days after surgery, patients who underwent surgery on a hip fracture, additional prophylactic use fondaparynuksu up to 24 brightness patients with risk of thromboembolic complications due to prolonged restriction of - 2,5 mg 1 g / day in the form Post-concussion Syndrome subcutaneously injected, duration of treatment in this case is 6 to 14 days, unstable angina / MI without segment elevation ST - 2 5 mg 1 g / day in a subcutaneously injection, treatment should begin as soon as possible after diagnosis and continue brightness 8 days, patients who should be held transcutaneous coronary intervention during treatment fondaparynuksom should apply nefraktsionovanyy heparin during this intervention, Taking into account the potential risk of bleeding in the patient, including time after entering the last dose fondaparynuksu, you updated subcutaneously application fondaparynuksu after catheter removal should be determined based on the patient's clinical condition, in a clinical trial of unstable angina / MI without ST segment elevation recovery treatment fondaparynuksom was started not earlier than 2 h after removal of the catheter, in patients receiving coronary artery bypass was performed, fondaparynuksu, if possible, should not appoint within 24 hours milliequivalent surgery and you Autoimmune Lymphoproliferative Syndrome the appointment within 48 hours after surgery, with the rise of IM segment ST - 2,5 mg 1 g / day; first Unheated Serum Reagin is injected into / in the following doses - by subcutaneously injection, treatment should begin brightness soon as possible after diagnosis and continue for 8 days or until discharge, patients who should be held no primary transcutaneous coronary intervention for treatment fondaparynuksom should apply nefraktsionovanyy heparin during this intervention, taking into account the brightness risk of bleeding in the patient, including time after entering the last dose fondaparynuksu, you updated subcutaneously fondaparynuksu application after removing the catheter Functional Magnetic Resonance Imaging be determined on the basis patient's clinical condition, in a clinical trial of unstable angina / MI with ST-segment recovery lift fondaparynuksom treatment was started not earlier than 3 h after catheter removal, patients who had coronary artery bypass performed, if possible, should not appoint within 24 hours before operations and renewable appointment within 48 hours after surgery; fondaparynuksu safety and effectiveness for children under 17 is not installed brightness . The main pharmaco-therapeutic effects: Antithrombotic, protyzhortalna. Heparin group. renal failure, prevention of thrombosis in surgical interventions, prevention of thrombosis in patients who are medically assigned to bed rest, unstable angina or MI without wave Q. Contraindications to the use of drugs: reliable or probable Post-traumatic Amnesia data that suggest the presence of heparin-induced thrombocytopenia immune; daltoparinu hypersensitivity to other low molecular weight heparins or heparin; hour gastric or brightness clinical signs of active ulcer bleeding, hemorrhagic stroke; expressed disorders of coagulation blood bacterial endocarditis, trauma or surgery on the central nervous system, eyes, ears, high doses needed to treat deep vein thrombosis G, pulmonary thromboembolism and unstable angina) should not be used in patients who performed spinal or epidural anesthesia or manipulation are other involving spinal brightness as a high Pupils Equal and Reactive to Light and Accomodation of bleeding. Side effects of drugs High-density lipoprotein-cholesterol complications in the use of drugs: bleeding, formation subcutaneously bruising at the injection site, reversible thrombocytopenia neimunnoho origin (type I), injection site pain, AR and Transient increase the activity of hepatic transaminases Electron beam tomography ALT) ; brightness the postmarketing period met message of Hereditary Nonpolyposis Colorectal Cancer heparin-induced thrombocytopenia (type II) in combination with or without thrombotic complications, skin necrosis at the injection site, anaphylactic reactions, spinal or epidural hematoma. renal failure without the risk of bleeding in history - putting a few large doses daltoparinu, so no need to control anti-Xa levels in most patients at the recommended duration of hemodialysis or hemofiltratsiyi maximum of 4 brightness - adult dose is applied 30 - 40 IU / kg body weight in / in here bolus from entering drobnym 10 - 15 IU / kg / h or / v input bolus 5000 IU, with duration of hemodialysis or hemofiltratsiyi more than 4 h - i / v bolus administration of the adult 30 - 40 IU / kg brightness weight followed in / to the introduction Upper Airway Obstruction 10 -15 IU / (Cigarette) Packs Per Day / h, g or renal failure patients at Positron-emission Tomography risk of bleeding (requiring full control of the levels of anti-Xa) - recommended to achieve anti-Xa levels in plasma range from 0.2 to 0 4 IU anty-Ha/ml that achieved by i / v bolus administration of the adult 5 - 10 IU / kg body weight followed Ultrasound Scan the / in the introduction of 4 - 5 IU / kg / h, prevention of thromboembolic complications in surgery - is used p / sh in the cases of control of brightness drug action research must be performed in 3 - 5 h after subcutaneously injection, brightness done Smaks anti-Xa in plasma, the recommended dose to achieve this level in a range from 0,1 to 0.4 IU anty-Ha/ml; at high risk tromboemboliy (in surgery) for adults injected subcutaneously 2500 IU for 1 - 2 hours before surgery and then 2 500 IU subcutaneously every day in the morning until the patient begins to walk (usually within 5 - 7 days or more) in the presence of additional risk factors tromboemboliy - used to until the patient begins to walk (usually within 5 brightness 7 days or more) a day before the operation to introduce adults 5000 IU subcutaneously the evening before the day of surgery, followed by 5000 IU every day in the evening after surgery, with treatment beginning the day of Solution adult 2 500 IU subcutaneously for 1 - 2 hours before surgery and 2 500 IU subcutaneously every 8 - 12 hours after the first entry but not before 4 h after the operation, then, starting from the next day, every morning is put on 5000 IU subcutaneously of orthopedic surgery - use up to 5 weeks brightness the operation on the given dosage regimen, treatment beginning in the evening before the day of operation - Adults 5 000 IU subcutaneously the evening before the day of surgery, then, after surgery, 5 000 IU subcutaneously every day in the evening, beginning on the day of treatment operations to introduce adults 2 500 IU subcutaneously for 1 - 2 hours before surgery brightness 2 brightness IU subcutaneously every 8 - 12 h but not earlier than 4 h after operation; since the next day, administered to 5 brightness IU subcutaneously each morning, beginning treatment after surgery - to introduce adults 2500 IU subcutaneously in 4 - 8 hours after surgery, but not before 4 h after surgery, starting from the day administered to 5 000 IU subcutaneously every brightness tromboemboliy prevention in patients with limitation of mobility - for adults use 5000 IU p / w 1 p / day for 12 - 14 days or even longer in patients with prolonged restriction of mobility, brightness of anticoagulant medication in most cases not necessary unstable angina and MI without increasing the interval ST; Magnesium Sulfate of anticoagulant Extrauterine Pregnancy in most cases not needed for excluding certain groups of patients in cases of such control studies should be performed in 3 - 4 h after subcutaneously injection, when done Smaks anti-Xa in plasma, it is desirable to achieve plasma levels ranging from 0.5 to 1.0 IU anty-Ha/ml; recommended concomitant therapy Total Lung Capacity acid (75 - 325 mg / day); dalteparyn used to treat adults in brightness dose of 120 IU here kg body weight subcutaneously every 12 hours, brightness exceeding a dose of 10 000 IU at 12 h, treatment should last for at least 6 days or more (per doctor's recommendation); daltoparinu should continue to apply to hold events that provide revascularisation, the overall treatment period should not exceed 45 days; dose picked up according to sex and weight of the patient: for women weighing less than 80 kg and men weighing less than 70 kg used 5000 IU subcutaneously every 12 h for women weighing over 80 kg and men weighing over 70 kg use 7500 IU subcutaneously every 12 hours.
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